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Updated: Jun 2, 2026
07:36
Angiogenesis in the Ischemic Rat Lung
Published on: February 8, 2013
Pulmonary adenocarcinoma angiogenesis
I Takanami1, F Tanaka, T Hashizume
1TEIKYO UNIV,SCH MED,DEPT PATHOL,ITABASHI KU,TOKYO 173,JAPAN. KANAGAWA HOSP,NATL SANATORIUM,DEPT SURG,KANAGAWA,JAPAN.
International Journal of Oncology
|May 3, 2011
Summary
Reduced expression of basic fibroblast growth factor (bFGF), transforming growth factor-beta 1 (TGF-beta 1), and vascular endothelial growth factor (VEGF) indicates better pulmonary adenocarcinoma prognosis. bFGF expression is a key survival marker.
Area of Science:
- Oncology
- Molecular Biology
- Pathology
Background:
- Angiogenesis is crucial for tumor growth and metastasis.
- Specific growth factors like bFGF, TGF-beta 1, and VEGF are key regulators of angiogenesis.
- Pulmonary adenocarcinoma prognosis can be influenced by tumor microenvironment factors.
Purpose of the Study:
- To investigate the correlation between bFGF, TGF-beta 1, and VEGF expressions and microvascular density in pulmonary adenocarcinoma.
- To evaluate the prognostic significance of these angiogenic factors, individually and in combination with F8RA, in pulmonary adenocarcinoma.
- To determine if bFGF expression serves as a predictive biomarker for patient survival.
Main Methods:
- Quantitative analysis of bFGF, TGF-beta 1, and VEGF expression levels in tumor tissues.
- Assessment of microvascular density using factor 8-related antigen (F8RA) as a marker.
- Correlation analysis between growth factor expression, microvascular density, and patient survival data.
- Multivariate analysis to identify independent prognostic factors.
Main Results:
- All three angiogenic factors (bFGF, TGF-beta 1, VEGF) showed a significant correlation with microvascular density.
- Reduced expression of bFGF, TGF-beta 1, and VEGF was associated with decreased tumor angiogenesis.
- Lower expression of these factors correlated with a better prognosis for pulmonary adenocarcinoma patients.
- Multivariate analysis confirmed that bFGF expression is an independent predictor of survival.
Conclusions:
- bFGF, TGF-beta 1, and VEGF play critical roles in the angiogenesis of pulmonary adenocarcinoma.
- Reduced expression of these factors is linked to less tumor angiogenesis and improved patient outcomes.
- bFGF expression is a valuable prognostic biomarker for pulmonary adenocarcinoma, aiding in outcome assessment.
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