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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol.

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Related Experiment Video

Updated: Jun 2, 2026

Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
07:12

Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions

Published on: July 17, 2020

Chlorophylls as anticarcinogens (review).

R Dashwood

    International Journal of Oncology
    |May 3, 2011
    PubMed
    Summary

    Sodium-copper chlorophyllin (CHL) shows promise as a cancer chemopreventive agent, particularly against aromatic carcinogens. Its effectiveness is highest when administered concurrently with the carcinogen, forming a molecular complex.

    Area of Science:

    • Biochemistry
    • Pharmacology
    • Oncology

    Background:

    • Chlorophylls and related porphyrins have established clinical uses, including photodynamic therapy.
    • Emerging research highlights the cancer chemopreventive potential of chlorophyll derivatives.
    • Sodium-copper chlorophyllin (CHL) is a water-soluble chlorophyll salt used clinically.

    Purpose of the Study:

    • To evaluate the anticarcinogenic activity of sodium-copper chlorophyllin (CHL).
    • To investigate the chemopreventive role of CHL against various aromatic carcinogens.
    • To elucidate the in vivo mechanisms of CHL's action in cancer prevention.

    Main Methods:

    • In vivo studies in rats, mice, and rainbow trout exposed to carcinogens.
    • Administration of CHL simultaneously with or after carcinogen exposure.

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    Published on: June 26, 2018

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    Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
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    Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
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    Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

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  • Analysis of biomarkers and carcinogenic endpoints.

    • Main Results:

    • CHL demonstrated chemopreventive effects against aflatoxins, polycyclic aromatic hydrocarbons, and heterocyclic amines.
    • Simultaneous administration of CHL with carcinogens proved most effective, suggesting molecular complex formation.
    • Post-initiation treatment with CHL yielded mixed results, indicating potential for both inhibition and promotion.

    Conclusions:

    • CHL exhibits significant chemopreventive properties against a range of aromatic carcinogens.
    • The timing of CHL administration is crucial, with concurrent application being most beneficial.
    • Further research is needed to fully understand the dual role of CHL in carcinogenesis and its dietary relevance.