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Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

p53 gene alterations are associated with a decreased responsiveness to neoadjuvant chemotherapy in human breast

S Lizardnacol1, B Coudert, J Riedinger

  • 1CTR GEORGES FRANCOIS LECLERC,ONCOL SERV,F-21034 DIJON,FRANCE. CTR GEORGES FRANCOIS LECLERC,MED BIOL LAB,F-21034 DIJON,FRANCE.

International Journal of Oncology
|May 3, 2011
PubMed

Insights

p53 gene alterations in breast cancer tumors are linked to resistance to chemotherapy. This finding suggests p53 status could predict treatment response in patients receiving neoadjuvant chemotherapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Alterations in the p53 tumor suppressor gene are implicated in cancer development and progression.
  • The p53 gene plays a crucial role in cellular responses to DNA damage and can influence drug resistance in tumor cells.

Purpose of the Study:

  • To investigate the association between p53 gene alterations and the response to neoadjuvant chemotherapy in breast cancer patients.
  • To determine if p53 status (mutations and mRNA expression) can predict clinical resistance to chemotherapy.

Main Methods:

  • Analysis of p53 gene status, including mutations and mRNA expression levels, in primary breast tumors.
  • Examination of p53 status before and after neoadjuvant chemotherapy treatment.
  • Comparison of clinical response rates between patients with and without p53 alterations.

Main Results:

  • p53 gene alterations were identified in 11 out of 44 patients (25%).
  • A significant association was found between p53 alterations and clinical resistance to chemotherapy (p<0.001).

Conclusions:

  • p53 alterations are strongly correlated with resistance to chemotherapy in breast cancer.
  • Assessing p53 status may offer a predictive biomarker for chemotherapy response in breast cancer patients.

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