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Innovative Adipose Tissue Fractionation for Transforming Fat into Specialized Components
Published on: July 11, 2025
Autologous cell-enriched fat grafting for breast augmentation
1Cosmetic Surgery Seishin, Pyramide 2F, 6-6-9 Roppongi, Minato-ku, Tokyo, 106-0032, Japan. tatsu@biyougeka.com
Aesthetic Plastic Surgery
|May 3, 2011
Summary
Autologous fat grafting enhanced with adipose-derived regenerative cells (ADRCs) offers a safe and effective method for breast augmentation. This study shows significant improvements in breast measurements and high patient satisfaction, supporting its clinical use.
Area of Science:
- Plastic Surgery
- Regenerative Medicine
- Adipose Tissue Engineering
Background:
- Autologous fat grafting for breast augmentation has historically faced challenges but is gaining acceptance.
- Enhancing fat grafts with autologous adipose-derived regenerative cells (ADRCs) is being explored to improve outcomes.
Observation:
- A prospective study involved 20 Japanese women undergoing breast augmentation with ADRC-enriched fat grafts.
- Adipose tissue was harvested via liposuction and processed using the Celution 800 System to isolate ADRCs, yielding an average of 3.42 × 10^5 cells/gram with 85.3% viability.
Findings:
- All patients showed improved breast measurements (BRM) within 3 months, with a mean increase of 3.3 cm at 9 months.
- Physician and patient satisfaction rates were 69% and 75%, respectively, at 9 months.
- The procedure was safe and well-tolerated, with no serious adverse events reported, though two patients developed postoperative cysts.
Implications:
- ADRC-enriched fat grafts processed via a closed automated system demonstrate high cell viability and procedural safety.
- The technique is effective for breast augmentation, with all patients showing improvement after a single treatment.
- This supports the use of ADRC-enhanced fat grafting as a viable option for breast augmentation.
