Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Reduced Coenzymes NADH and FADH₂

Role of Reduced Coenzymes NADH and FADH₂

The energy released from the breakdown of the chemical bonds within nutrients can be stored either through the reduction of electron carriers or in the bonds of adenosine triphosphate (ATP). In living systems, a small class of compounds functions as mobile electron carriers, molecules that bind to and shuttle high-energy electrons between compounds in pathways. The principal electron carriers that will be considered originate from the B vitamin group and are derivatives of nucleotides; they are...

Other Nuclides: 31P, 19F, 15N NMR

Other Nuclides: ³¹P, ¹⁹F, ¹⁵N NMR

Many organic, inorganic, and biological molecules contain spin-half nuclei such as nitrogen-15, fluorine-19, and phosphorus-31. As a result, NMR studies of these nuclei have found extensive applications in chemical and biological research.
While fluorine-19 and phosphorous-31 have high natural abundances (100%) and positive gyromagnetic ratios, nitrogen-15 has a low natural abundance and a negative gyromagnetic ratio. However, nitrogen-15 is still preferred over nitrogen-14 (which has a high...

Oxidation and Reduction of Organic Molecules

Oxidation and Reduction of Organic Molecules

Energy production within a cell involves many coordinated chemical pathways. Most of these pathways are combinations of oxidation and reduction reactions, which occur at the same time. An oxidation reaction strips an electron from an atom in a compound, and the addition of this electron to another compound is a reduction reaction. Because oxidation and reduction usually occur together, these pairs of reactions are called redox reactions.
The removal of an electron from a molecule, results in a...

Biosynthesis of Nucleic Acids

Biosynthesis of Nucleic Acids

Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...

Changes in Skin Color: Clinical Perspectives

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

Overview of Metabolism

Overview of Metabolism

Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

La<sub>0.2</sub>Sr<sub>0.25</sub>Ca<sub>0.45</sub>TiO<sub>3</sub> Surface Reactivity with H<sub>2</sub>: A Combined <i>Operando</i> NEXAFS and Computational Study.

The journal of physical chemistry letters·2024

Same author

OnabotulinumtoxinA in elderly patients with chronic migraine: insights from a real-life European multicenter study.

Journal of neurology·2022

Same author

An integrated ultra-high vacuum apparatus for growth and in situ characterization of complex materials.

The Review of scientific instruments·2020

Same author

A reaction cell for ambient pressure soft x-ray absorption spectroscopy.

The Review of scientific instruments·2018

Same author

Establishment of an Italian chronic migraine database: a multicenter pilot study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2018

Same author

Spectroscopic identification of the chemical interplay between defects and dopants in Al-doped ZnO.

Physical chemistry chemical physics : PCCP·2017

Same journal

Early and severe masticatory muscle involvement in SOD1-ALS: a case report with biomarker-clinical dissociation.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026

Same journal

Early multimodal predictors of good neurological outcome in comatose patients after cardiac arrest: a prospective single-center cohort study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026

Same journal

Telemedicine for headache disorders in real-world practice: from patient experience to health system impact.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026

Same journal

Topography and functional connectivity analysis of heart surgery-associated brain lesions: a literature review.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026

Same journal

Limb apraxia in Parkinson's disease and atypical parkinsonian syndromes: a systematic review.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026

Same journal

Primary Sjogren syndrome with suspected central nervous system inflammatory involvement.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Detection of Microregional Hypoxia in Mouse Cerebral Cortex by Two-photon Imaging of Endogenous NADH Fluorescence

Detection of Microregional Hypoxia in Mouse Cerebral Cortex by Two-photon Imaging of Endogenous NADH Fluorescence

Published on: February 21, 2012

Does NDPH exist? Some clinical considerations.

G C Manzoni¹, P Torelli

¹Centro Cefalee, Azienda Ospedaliero-Universitaria Dipartimento di Neuroscienze, University of Parma, Via Gramsci, 14, 43100 Parma, Italy. giancamillo.manzoni@unipr.it

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|May 3, 2011

Summary

This summary is machine-generated.

New daily persistent headache (NDPH) diagnostic criteria are inadequate. Further research into systemic diseases, psychiatric links, and stress factors is needed to determine if primary NDPH truly exists.

More Related Videos

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

Related Experiment Videos

Last Updated: Jun 2, 2026

Detection of Microregional Hypoxia in Mouse Cerebral Cortex by Two-photon Imaging of Endogenous NADH Fluorescence

Detection of Microregional Hypoxia in Mouse Cerebral Cortex by Two-photon Imaging of Endogenous NADH Fluorescence

Published on: February 21, 2012

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

Area of Science:

Neurology
Headache Medicine
Psychiatry

Background:

The International Classification of Headache Disorders (ICHD-II) criteria for new daily persistent headache (NDPH) may not be fully adequate.
Current diagnostic criteria sometimes misalign headache features with expected classifications like tension-type headache.

Purpose of the Study:

To evaluate the adequacy of current ICHD-II diagnostic criteria for NDPH.
To identify necessary considerations beyond current criteria for accurate NDPH diagnosis.

Main Methods:

Analysis of published case series on NDPH.
Clinical evaluation of patients diagnosed with NDPH at headache clinics.

Main Results:

The current ICHD-II criteria for NDPH appear insufficient.
Headache characteristics in some NDPH patients do not align with ICHD-II expectations for tension-type headaches.

Conclusions:

Accurate NDPH diagnosis requires ruling out underlying systemic diseases.
Investigating psychiatric comorbidity and the role of stressful life events is crucial for NDPH assessment.
Future improvements in classifying psychiatric-related headaches and thorough psychological evaluations are needed to ascertain the existence of primary NDPH.