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Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

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¹David Geffen School of Medicine at UCLA, 239 South Orange Drive, Los Angeles, CA 90036, USA. alanrapoport@gmail.com

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|May 3, 2011

Summary

This summary is machine-generated.

New acute migraine treatments are in development, focusing on faster, easier administration with fewer side effects. Investigated therapies include CGRP antagonists and novel delivery methods for existing medications like sumatriptan.

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Area of Science:

Neurology
Pharmacology

Background:

Migraine treatment options are limited, especially for prevention, with few new approvals in recent decades.
Acute migraine care has seen more options, including triptans and NSAIDs, but faster, safer administration methods are sought.

Purpose of the Study:

To review the development progress of four novel acute migraine medications.
To highlight advancements in drug delivery for improved migraine management.

Main Methods:

Review of emerging acute migraine therapies.
Focus on CGRP antagonist telcagepant, sumatriptan iontophoretic patch, sumatriptan powder (OptiNose), and dihydroergotamine inhaler.

Main Results:

Several new acute migraine treatments are under investigation, including novel formulations and delivery systems.
The development pipeline includes CGRP antagonists and improved administration methods for triptans and dihydroergotamine.

Conclusions:

Advancements in acute migraine therapy aim for enhanced efficacy, faster onset, and improved patient experience.
Novel drug delivery systems and new pharmacological targets show promise for future migraine management.