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Blood cells characteristics as determinants of acute myocardial infarction

Roberto Cemin1, Luca Donazzan, Giuseppe Lippi

  • 1Department of Cardiology, San Maurizio Regional Hospital, Bolzano, Italy.

Clinical Chemistry and Laboratory Medicine
|May 4, 2011
PubMed

Insights

Mean platelet volume (MPV) and red blood cell distribution width (RDW) show potential in identifying acute myocardial infarction (AMI), with notable gender differences. These red blood cell and platelet morphology markers may supplement cardiac biomarkers for early AMI detection.

Area of Science:

  • Hematology
  • Cardiology
  • Clinical Diagnostics

Background:

  • Acute myocardial infarction (AMI) diagnosis relies on cardiac biomarkers.
  • Red blood cell and platelet morphology may offer additional diagnostic insights.
  • Early identification of AMI is crucial for patient outcomes.

Purpose of the Study:

  • To analyze the relationship between red blood cell and platelet morphology and AMI.
  • To assess if these morphological parameters can supplement traditional cardiac biomarkers for early AMI identification.

Main Methods:

  • Consecutive patients with suspected cardiac chest pain were included.
  • Standard diagnostic workup included ECG, cardiac troponin I, and complete blood count.
  • Morphological parameters like mean corpuscular volume (MCV), red blood cell distribution width (RDW), platelets count (Plt), and mean platelet volume (MPV) were analyzed.

Main Results:

  • Mean platelet volume (MPV) was significantly higher in AMI patients.
  • Men with AMI showed lower RDW and higher MPV compared to non-AMI men.
  • Women with AMI exhibited higher RDW compared to non-AMI women.

Conclusions:

  • MPV and RDW show partial confirmation of association with AMI.
  • These parameters may complement conventional cardiac biomarkers in suspected AMI evaluation.
  • Gender-specific differences in MPV and RDW in AMI must be considered.
Abstract

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