Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Right versus left pulmonary artery anastomosis of the right ventricle-to-pulmonary artery conduit in Norwood procedure: Comparable outcomes with longer Glenn operative time.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Successful transcatheter closure of a congenital aorto-right ventricular fistula after Norwood procedure.

JTCVS techniques·2026
Same author

Increased Risk of Disabilities in Children and Adolescents With Congenital Heart Disease of Any Severity.

Journal of the American Heart Association·2026
Same author

A three generation family with VACTERL association is found to have a rare form of diamond-blackfan anaemia.

European journal of human genetics : EJHG·2026
Same author

Long-Term Outcomes of the Norwood Operation: Why We Are Surprised But Should Not Be.

Journal of the American College of Cardiology·2026
Same author

When the stakes are high and the supports are low: emotional exhaustion among health professionals working in paediatric cardiac care.

Cardiology in the young·2026

Related Experiment Video

Updated: Jun 2, 2026

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development
04:37

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development

Published on: June 16, 2023

Hypoplastic left heart syndrome in context.

David S Winlaw1, Nadia Badawi, Stephen Jacobe

  • 1Heart Centre for Children, The Children's Hospital at Westmead, New South Wales, Australia. davidw@chw.edu.au

Journal of Paediatrics and Child Health
|May 4, 2011
PubMed
Summary

Hypoplastic left heart syndrome (HLHS) requires neonatal surgery and Fontan circulation. Care algorithms offer predictable outcomes, guiding parental choices with antenatal diagnosis.

More Related Videos

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart
08:22

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart

Published on: April 15, 2020

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

Related Experiment Videos

Last Updated: Jun 2, 2026

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development
04:37

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development

Published on: June 16, 2023

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart
08:22

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart

Published on: April 15, 2020

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

Area of Science:

  • Pediatric Cardiology
  • Congenital Heart Disease Surgery

Background:

  • Hypoplastic left heart syndrome (HLHS) is a rare congenital heart defect.
  • It necessitates complex neonatal cardiac surgery and staged palliation.
  • The Fontan circulation is the ultimate goal for single-ventricle physiology.

Purpose of the Study:

  • To review the established care algorithms for HLHS.
  • To highlight predictable medium-term outcomes.
  • To inform parental choice through antenatal diagnosis.

Main Methods:

  • Review of existing literature and care guidelines for HLHS.
  • Analysis of outcomes associated with Fontan circulation completion.
  • Discussion of the role of antenatal diagnosis.

Main Results:

  • Care algorithms for HLHS are well-defined.
  • The majority of patients achieve Fontan circulation with predictable medium-term outcomes.
  • Antenatal diagnosis is common and informs management.

Conclusions:

  • Established care pathways lead to successful Fontan circulation in most HLHS patients.
  • Understanding outcomes aids in informed parental decision-making.
  • HLHS management benefits from a standardized perioperative approach.