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Published on: November 23, 2014
Intussusceptive angiogenesis: pillars against the blood flow
B Styp-Rekowska1, R Hlushchuk, A R Pries
1Institute of Anatomy, University of Bern, Bern, Switzerland.
Acta Physiologica (Oxford, England)
|May 4, 2011
Summary
Vascular networks adapt through vessel growth and remodelling, influenced by blood flow biomechanics. This study overviews intussusceptive angiogenesis and its relation to local hemodynamics.
Area of Science:
- Cardiovascular Biology
- Angiogenesis Research
- Hemodynamics
Background:
- Vascular network adaptation involves vessel growth, regression, and remodeling.
- Biomechanical forces from blood flow are crucial for vascular adaptation.
- Metabolic stimuli, mechanical forces, and flow patterns influence vascular gene expression and remodeling.
Purpose of the Study:
- To provide an overview of angiogenic processes.
- To focus on intussusceptive angiogenesis.
- To relate intussusceptive angiogenesis to local hemodynamics.
Main Methods:
- Literature review of angiogenesis.
- Analysis of vascular remodeling mechanisms.
- Examination of hemodynamic influences on vascular patterns.
Main Results:
- Sprouting angiogenesis (hypoxia-related) lacks initial blood flow.
- Increased wall shear stress can initiate splitting angiogenesis in skeletal muscle.
- Both sprouting and intussusceptive angiogenesis occur during development, with distinct spatiotemporal patterns.
Conclusions:
- Flow dynamics, alongside regulatory molecules, contribute to vascular tree patterning and remodeling.
- Intussusceptive angiogenesis is significantly influenced by local hemodynamic conditions.
- Understanding hemodynamic roles is key for vascular adaptation research.
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