Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Convergent effects of synthetic glucocorticoid dexamethasone and amyloid beta in human olfactory neurosphere-derived cells.

Journal of neurochemistry·2024
Same author

Ataxia Telangiectasia patient-derived neuronal and brain organoid models reveal mitochondrial dysfunction and oxidative stress.

Neurobiology of disease·2024
Same author

Reduced acetylated α-tubulin in <i>SPAST</i> hereditary spastic paraplegia patient PBMCs.

Frontiers in neuroscience·2023
Same author

An Alzheimer's Disease Patient-Derived Olfactory Stem Cell Model Identifies Gene Expression Changes Associated with Cognition.

Cells·2022
Same author

Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer's Disease Patients.

Cells·2022
Same author

Directional Persistence of Cell Migration in Schizophrenia Patient-Derived Olfactory Cells.

International journal of molecular sciences·2021
Same journal

Transplantation of human umbilical mesenchymal stromal cells attenuates heart failure progression in a rat model.

Cell transplantation·2026
Same journal

Three-dimensionally printed mesoporous bioactive glass for craniomaxillofacial bone regeneration: Material evolution, functional mechanisms, and clinical translation.

Cell transplantation·2026
Same journal

Hotspots and trends in stem cell therapy for ligament injuries: A bibliometric analysis (2001-2025).

Cell transplantation·2026
Same journal

Amniotic epithelial cells enhance islet engraftment by suppressing early inflammation in intraportal transplantation.

Cell transplantation·2026
Same journal

Cdc42-Modified BMSC-Derived exosomes promote acellular nerve allografts to bridge sciatic nerve defects.

Cell transplantation·2026
Same journal

Organ-on-a-chip as a next-generation tool in drug development: A bibliometric and patent analysis.

Cell transplantation·2026
See all related articles

Related Experiment Video

Updated: Jun 2, 2026

Isolating Nasal Olfactory Stem Cells from Rodents or Humans
09:19

Isolating Nasal Olfactory Stem Cells from Rodents or Humans

Published on: August 22, 2011

Characterization of olfactory stem cells.

Andrew Wetzig1, Alan Mackay-Sim, Wayne Murrell

  • 1Eskitis Institute for Cell and Molecular Therapies, National Centre for Adult Stem Cell Research, Griffith University, Nathan, Queensland, Australia.

Cell Transplantation
|May 4, 2011
PubMed
Summary
This summary is machine-generated.

Olfactory neural stem cells are multipotent and can repair organs. Culture methods enrich these stem cells, enhancing their potential for regenerative medicine and tissue repair strategies.

More Related Videos

Rapid Dissection and Dissociation of the Mouse Olfactory Epithelium for Single-Nucleus Suspensions
03:42

Rapid Dissection and Dissociation of the Mouse Olfactory Epithelium for Single-Nucleus Suspensions

Published on: August 1, 2025

Related Experiment Videos

Last Updated: Jun 2, 2026

Isolating Nasal Olfactory Stem Cells from Rodents or Humans
09:19

Isolating Nasal Olfactory Stem Cells from Rodents or Humans

Published on: August 22, 2011

Rapid Dissection and Dissociation of the Mouse Olfactory Epithelium for Single-Nucleus Suspensions
03:42

Rapid Dissection and Dissociation of the Mouse Olfactory Epithelium for Single-Nucleus Suspensions

Published on: August 1, 2025

Area of Science:

  • Regenerative Medicine
  • Neuroscience
  • Stem Cell Biology

Background:

  • Cellular transplant therapy holds promise for organ repair.
  • Olfactory mucosa offers an accessible source of multipotent cells.
  • Olfactory neural stem cells are candidates for tissue repair strategies.

Purpose of the Study:

  • Investigate the biology of olfactory neural stem cells in rats.
  • Determine stem cell frequency and culture enrichment.
  • Examine stem cell multipotency and differentiation triggers.

Main Methods:

  • Utilized rat olfactory mucosa for cell sourcing.
  • Assessed self-renewal capacity and phenotypic acquisition.
  • Employed culture systems to select and enrich stem cells.

Main Results:

  • Olfactory stem cells demonstrated multipotency by adopting new phenotypes in different niches.
  • Stem cell numbers were significantly enriched by culture methods.
  • Differentiation capacity is triggered by environmental niche signals.

Conclusions:

  • Adult olfactory stem cells exhibit plasticity and multipotency.
  • Culture enrichment strategies enhance stem cell yield for regenerative applications.
  • Olfactory neural stem cells are a promising source for tissue regeneration.