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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Therapeutic Massage for Psychological Well-being in Geriatric Oncology
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Immunity, aging, and geriatric depression.

Sarah Shizuko Morimoto1, George S Alexopoulos

  • 1Weill Cornell Institute of Geriatric Psychiatry, 21 Bloomingdale Road, White Plains, NY 10605, USA.

The Psychiatric Clinics of North America
|May 4, 2011
PubMed
Summary
This summary is machine-generated.

Inflammation plays a key role in geriatric depression, worsening other health issues. Treating inflammation and related conditions may improve overall health in older adults with depression.

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Area of Science:

  • Geriatric psychiatry
  • Neuroimmunology
  • Psychoneuroimmunology

Background:

  • Geriatric depression is linked to illnesses involving inflammatory processes.
  • Aging and depression share associations with immune responses.
  • Inflammatory responses may modulate mood-regulating brain connectivity.

Purpose of the Study:

  • To explore the causal role of inflammation in geriatric depression.
  • To understand how inflammation interacts with aging and depression.
  • To highlight the impact of geriatric depression on comorbid conditions.

Main Methods:

  • Review of existing literature on inflammation, aging, and depression.
  • Analysis of the relationship between chronic stress and proinflammatory responses.
  • Examination of the effects of treating comorbid conditions on CNS inflammation.

Main Results:

  • Inflammatory processes are implicated in the pathogenesis of geriatric depression.
  • Geriatric depression exacerbates symptoms of co-occurring disorders.
  • Chronic stress is a significant factor precipitating geriatric depression and inflammation.

Conclusions:

  • Inflammation is a likely causal factor in geriatric depression.
  • Treating comorbid conditions that elevate central nervous system inflammation offers general health benefits.
  • Clinical practice should incorporate the management of inflammation in geriatric depression care.