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Isolation of Salmonella typhimurium-containing Phagosomes from Macrophages
Published on: October 25, 2017
Occurrence & antibiogram of Salmonella Typhi & S. Paratyphi A isolated from Rourkela, Orissa
S S Bhattacharya1, Usha Das, B K Choudhury
1Department of Microbiology, Ispat General Hospital, Rourkela, India.
The Indian Journal of Medical Research
|May 4, 2011
Summary
Salmonella Typhi and Salmonella Paratyphi A cause year-round infections in Rourkela. While Salmonella Typhi remains susceptible to many antibiotics, increasing resistance in Salmonella Paratyphi A is a concern.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Salmonella Typhi and Salmonella Paratyphi A have shown persistent year-round presence in Rourkela for over a decade.
- Enteric fever and pyrexia of unknown origin are significant health concerns in the region.
Purpose of the Study:
- To investigate the incidence and antimicrobial susceptibility patterns of Salmonella Typhi and Salmonella Paratyphi A in Rourkela.
- To assess the prevalence of multidrug resistance in these key enteric fever pathogens.
Main Methods:
- Prospective study conducted at Ispat General Hospital, Rourkela, India, from January 2005 to December 2008.
- Analysis of 5340 blood samples from patients with suspected enteric fever or pyrexia of unknown origin.
- Standard bacteriological procedures for isolation, identification, and antibiogram determination of Salmonella isolates.
Main Results:
- A total of 298 Salmonella isolates were identified, yielding a positivity rate of 5.58%.
- Multidrug resistance was observed in 11.96% of Salmonella Typhi and 15.62% of Salmonella Paratyphi A isolates.
- Low resistance rates (<2%) were noted for ciprofloxacin, and 3.0-6.25% resistance to third-generation cephalosporins was found.
Conclusions:
- Year-round Salmonella circulation in Rourkela may be linked to carriers, poor sanitation, and contaminated water supply.
- Encouraging susceptibility of Salmonella Typhi to various antibiotics contrasts with a concerning rise in Salmonella Paratyphi A resistance.
- Continuous monitoring of antimicrobial resistance patterns is crucial for effective treatment strategies.
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