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Sampling variability of transient elastography according to probe location.

Shira Zelber-Sagi1, Hanny Yeshua, Amir Shlomai

  • 1Department of Gastroenterology and Liver, Tel Aviv Sourasky Medical Center, Israel.

European Journal of Gastroenterology & Hepatology
|May 4, 2011
PubMed
Summary
This summary is machine-generated.

Liver stiffness measurements using transient elastography can vary by probe location in about 30% of patients. Performing measurements at multiple sites may reduce sampling errors in diagnosing liver fibrosis.

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Area of Science:

  • Hepatology
  • Medical Imaging
  • Diagnostic Techniques

Background:

  • Liver fibrosis heterogeneity is known.
  • Transient elastography (TE) requires further investigation regarding multiple measurements.
  • Probe location's impact on TE measurements is not well-studied.

Purpose of the Study:

  • To investigate if liver stiffness measurements vary based on probe location.
  • To assess the impact of sampling variability in transient elastography.

Main Methods:

  • 625 patients with chronic liver disease underwent TE.
  • Three successive liver stiffness measurements were taken at different sites per patient.
  • Representative measurements met success rate >60% and interquartile range <30%.

Main Results:

  • 371 patients had three representative measurements.
  • 68.2% showed agreement across all three sites; discordance occurred in 31.8%.
  • Fibrosis stage influenced discordance, with higher variability in stages F2-F3.

Conclusions:

  • Sampling variability due to probe location occurs in approximately 30% of TE measurements.
  • Performing TE at multiple sites is recommended to minimize sampling error.
  • This variability impacts accurate non-invasive staging of liver fibrosis.