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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Genetic Lingo01:11

Genetic Lingo

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Related Experiment Video

Updated: Jun 2, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Credible genetic associations?

Marcus R Munafò1

  • 1Department of Experimental Psychology, University of Bristol United Kingdom.

International Journal of Molecular Epidemiology and Genetics
|May 4, 2011
PubMed
Summary
This summary is machine-generated.

Genetic association studies require stricter standards due to replication failures. New guidelines from the Human Genome Epidemiology Network aim to improve the credibility of genetic findings.

Keywords:
Genetic associationHuGENetMeta-Analysisreplication

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Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)
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Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)

Published on: April 19, 2013

Related Experiment Videos

Last Updated: Jun 2, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)
09:52

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)

Published on: April 19, 2013

Area of Science:

  • Genetics
  • Epidemiology
  • Biostatistics

Background:

  • Genetic association studies have increased significantly.
  • Many initial findings fail to replicate robustly.
  • This highlights the need for stringent standards in genetic research.

Purpose of the Study:

  • To review the Human Genome Epidemiology Network's guidelines on evidential criteria for genetic association studies.
  • To discuss the value and importance of these guidelines.
  • To assess the potential impact of these guidelines on future genetic association studies.

Main Methods:

  • Review of published guidelines.
  • Discussion of evidential criteria.
  • Analysis of potential impact on study conduct.

Main Results:

  • The Human Genome Epidemiology Network has published new guidelines.
  • These guidelines provide criteria for evaluating genetic association studies.
  • The guidelines are intended to enhance the credibility of genetic findings.

Conclusions:

  • Stringent standards are crucial for credible genetic associations.
  • The new guidelines offer a framework for improving genetic association studies.
  • Adoption of these guidelines is expected to impact the conduct and reliability of genetic research.