Related Experiment Video
Updated: Jun 2, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
Regulation of cancer cell migration and invasion by sphingosine-1-phosphate
1James R Van Brocklyn, Department of Pathology, The Ohio State University, Columbus, OH 43210, United States.
Abstract:
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that has been implicated in regulation of a number of cancer cell malignant behaviors, including cell proliferation, survival, chemotherapeutic resistance and angiogenesis. However, the effects of S1P on cancer cell migration, invasion and metastasis, are perhaps its most complex, due to the fact that, depending upon the S1P receptors that mediate its responses and the crosstalk with other signaling pathways, S1P can either positively or negatively regulate invasion. This review summarizes the effects of S1P on cancer cell invasion and the mechanisms by which it affects this important aspect of cancer cell behavior.
Related Concept Videos
Cancer Cell Migration through Invadopodia
Cell Migration
Cell Migration
Chemotaxis and Direction of Cell Migration
Cell Polarization by Rho Proteins
Cytoskeletal Coordination in Cell Migration

