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Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Published on: July 26, 2024

Recent advances in functional anorectal disorders.

Adil E Bharucha¹

¹Clinical and Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA. bharucha.adil@mayo.edu

Current Gastroenterology Reports

|May 4, 2011

Summary

Defecatory disorders causing chronic constipation are best treated with biofeedback-guided pelvic floor retraining. Fecal incontinence management starts with addressing bowel issues, with biofeedback therapy as a key treatment option.

Related Experiment Videos

Last Updated: Jun 2, 2026

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Published on: July 26, 2024

Area of Science:

Gastroenterology
Pelvic Floor Physical Therapy

Background:

Defecatory disorders frequently cause chronic constipation.
Obstetric anal injury and community-acquired diarrhea are risk factors for fecal incontinence (FI), particularly in women over 40.
Diagnosis of defecatory disorders often involves anorectal testing and digital rectal examination.

Purpose of the Study:

To outline the management of defecatory disorders and fecal incontinence.
To emphasize the role of pelvic floor retraining and biofeedback therapy.

Main Methods:

Review of current literature on defecatory disorders and fecal incontinence.
Focus on diagnostic approaches including digital rectal examination.
Evaluation of conservative and interventional treatment strategies.

Main Results:

Biofeedback-guided pelvic floor retraining is a primary management strategy for defecatory disorders.
Initial management of fecal incontinence involves addressing bowel disturbances.
Biofeedback therapy and sacral nerve stimulation are effective for refractory cases.

Conclusions:

Effective management of constipation and fecal incontinence relies on accurate diagnosis and tailored therapies.
Pelvic floor retraining with biofeedback offers significant benefits for patients.
Advanced therapies like sacral nerve stimulation should be considered when conservative treatments fail.