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Updated: Jun 2, 2026

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
Published on: July 14, 2010
Aβ oligomer-induced synapse degeneration in Alzheimer's disease
Kyle C Wilcox1, Pascale N Lacor, Jason Pitt
1Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA. k-wilcox@northwestern.edu
Abstract:
Aβ oligomers cause a collection of molecular events associated with memory loss in Alzheimer's disease, centering on disrupting the maintenance of synapse structure and function. In this brief review of the synaptotoxic effects of Aβ oligomers, we focus on the neuronal properties governing oligomer targeting and toxicity-especially with respect to binding sites and mechanisms of binding. We also discuss ways in which mechanistic insights from other diseases offer clues in the pursuit of the molecular basis of Alzheimer's disease.
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