Related Experiment Videos
Congenital cytomegalovirus infection as a preventable complication of maternal transfusion. A case report
J A McGregor1, G Rubright, J W Ogle
1Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver 80262.
Transfusion-mediated cytomegalovirus (CMV) infection among neonates and nonpregnant, adult female surgical patients has been described thoroughly. A case of symptomatic congenital CMV infection developed after a maternal transfusion during pregnancy. It is estimated that 2.5-12.5% of individual blood units mediate CMV infection though inadvertent transfusion of CMV-infected leukocytes. The use of CMV-seronegative or deglycerolized blood may eliminate or considerably reduce the risk of transfusion-mediated primary CMV infection in pregnant women and their fetuses. CMV-seronegative or deglycerolized blood is used routinely in the case of CMV-susceptible neonates and immunocompromised individuals who require a transfusion. Whenever possible, CMV-seronegative or deglycerolized blood should be used for transfusions in pregnant women who are CMV seronegative or whose serologic status is unknown.
Transfusion-mediated cytomegalovirus (CMV) infection among neonates and nonpregnant, adult female surgical patients has been described thoroughly. A case of symptomatic congenital CMV infection developed after a maternal transfusion during pregnancy. It is estimated that 2.5-12.5% of individual blood units mediate CMV infection though inadvertent transfusion of CMV-infected leukocytes. The use of CMV-seronegative or deglycerolized blood may eliminate or considerably reduce the risk of transfusion-mediated primary CMV infection in pregnant women and their fetuses. CMV-seronegative or deglycerolized blood is used routinely in the case of CMV-susceptible neonates and immunocompromised individuals who require a transfusion. Whenever possible, CMV-seronegative or deglycerolized blood should be used for transfusions in pregnant women who are CMV seronegative or whose serologic status is unknown.