T-cell lymphosarcoma in a female African green monkey (Cercopithecus aethiops)
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Updated: Nov 6, 2026
Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
Published on: December 23, 2016
M J Jayo1, K Laber-Laird, B C Bullock
1Department of Comparative Medicine, Bowman Gray School of Medicine, Wake Forrest University, Winston-Salem, NC 27103.
Abstract:
A female African green monkey developed a generalized lymphosarcoma spontaneously that clinically and pathologically resembled malignant lymphoma in human beings infected with human T-lymphotropic virus type I. The monkey was serologically positive for simian T-lymphotropic virus. Immunocytochemical analysis of routinely fixed and paraffin embedded tumor tissue demonstrated neoplastic cells that stained positive with antihuman monoclonal UCHL1 which recognized a T-cell-restricted isotype of leukocyte common antigen.
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