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06:02
Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
Published on: September 13, 2018
Viruses and the fuel sensor: the emerging link between AMPK and virus replication
1Institute of Molecular and Cellular Biology, University of Leeds, UK.
Reviews in Medical Virology
|May 4, 2011
Summary
Viruses can disrupt cellular energy balance by altering Adenosine 5' monophosphate-activated protein kinase (AMPK) activity. This review explores how viral interactions with AMPK impact virus persistence and cell damage.
Area of Science:
- Cellular metabolism
- Virology
- Biochemistry
Background:
- Adenosine 5' monophosphate-activated protein kinase (AMPK) is a crucial regulator of cellular energy homeostasis in eukaryotes.
- AMPK activation by increased AMP:ATP ratio upregulates catabolic and downregulates anabolic pathways.
- The role of viral modulation of AMPK in cellular function and infection has been underexplored.
Purpose of the Study:
- To review the emerging field of viral dysregulation of AMPK.
- To outline how various viruses stimulate or inhibit AMPK activity.
- To document the impact of AMPK perturbations on viral infection biology, persistence, and cytopathogenesis.
Main Methods:
- Literature review of studies investigating viral interactions with AMPK.
- Analysis of reported mechanisms of viral modulation of AMPK activity (stimulation or inhibition).
- Correlation of AMPK activity changes with viral infection outcomes.
Main Results:
- A growing body of evidence indicates diverse viral strategies to modulate AMPK.
- Viruses can either activate or inhibit AMPK, depending on the specific virus-host interaction.
- Perturbations in AMPK activity by viruses significantly influence viral persistence and the capacity to cause cell damage.
Conclusions:
- Viral manipulation of AMPK represents a significant factor in viral pathogenesis.
- Understanding these interactions is key to comprehending viral infection dynamics.
- Further research into virus-AMPK crosstalk may reveal novel therapeutic targets.
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