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Published on: November 16, 2011

Advanced glycation end products downregulate glucokinase in mice

Hongsoo Jung1, Jindeok Joo, Yeonsu Jeon

  • 1Department of Anesthesiolgy and Pain Medicine, Catholic Unversity of Saint Vincent Hospital, Suwon, Republic of Korea.

Diabetes/Metabolism Research and Reviews
|May 4, 2011
PubMed
Summary

Advanced glycation end products (AGEs) inhibit glucokinase activity, impairing glucose metabolism and leading to islet dysfunction. This study reveals AGEs negatively impact pancreatic islet function by reducing glucokinase levels and activity.

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