Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Toxicity Testing in Animals

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

Bioequivalence Data: Statistical Interpretation

Bioequivalence Data: Statistical Interpretation

The statistical interpretation of bioequivalence data is a significant aspect of pharmaceutical research. Bioequivalence refers to the absence of any significant difference in the rate and extent to which the active ingredient in pharmaceutical products becomes available at the site of drug action when administered at the same molar dose under similar conditions. This helps determine if different drug products have similar absorption rates, ensuring their interchangeability.Statistical...

Bioavailability Study Design: Single Versus Multiple Dose Studies

Bioavailability Study Design: Single Versus Multiple Dose Studies

Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...

Bioavailability Study Design: Absolute Versus Relative Bioavailability

Bioavailability Study Design: Absolute Versus Relative Bioavailability

Bioavailability is a crucial pharmacokinetic parameter that quantifies the proportion of an administered drug that reaches the systemic circulation and is available for therapeutic action. Regulatory agencies mandate the assessment of bioavailability, typically measured as the area under the drug plasma concentration-versus-time curve (AUC), to ensure the efficacy and safety of pharmaceutical products. These evaluations are categorized as absolute and relative bioavailability studies.Absolute...

Measurement of Bioavailability: Pharmacokinetic Methods

Measurement of Bioavailability: Pharmacokinetic Methods

Pharmacokinetics is a vital branch of pharmacology that examines how drugs are absorbed, distributed, metabolized, and excreted by the body. Two key methodologies in pharmacokinetics are plasma drug concentration studies and urinary drug excretion analyses, both of which provide critical insights into a drug's therapeutic efficacy and bioavailability.Plasma Drug Concentration-Time StudiesPlasma drug concentration-time studies involve analyzing blood samples at specific intervals to quantify...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Environmentally Safe and Just Pharmacy: A Framework and Action Plan for Operating within the Earth System Boundary for Novel Entities.

Environmental science & technology·2026

Same author

Impacts of environmental stressors on fertility and fecundity across taxa, with implications for planetary health.

NPJ emerging contaminants·2026

Same author

Mercury bioaccumulation and biomagnification in southern hemisphere riverine food webs: Environmental drivers across a 3,700 km Chilean latitudinal gradient.

Environmental pollution (Barking, Essex : 1987)·2026

Same author

An exploratory evaluation of the interaction risk between herbal products and pharmaceutical medicines used concurrently for disease management in Blantyre, Malawi.

Pharmaceutical biology·2025

Same author

Methylmercury bioaccumulation and biomagnification in streams within forested catchments defoliated by spruce budworm.

Environmental research·2025

Same author

Temporal and regional effects of forest harvesting on mercury bioaccumulation and biomagnification in boreal stream food webs.

Environmental research·2025

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

Bioaccumulation data from laboratory and field studies: are they comparable?

Lawrence P Burkhard¹, Christina Cowan-Ellsberry, Michelle R Embry

¹US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Congdon Boulevard, Duluth, MN 55804, USA. burkhard.lawrence@epa.gov

Integrated Environmental Assessment and Management

|May 4, 2011

Summary

Predicting chemical bioaccumulation in wildlife is challenging. This workshop compared lab and field data, offering recommendations to improve bioaccumulation assessments for environmental safety.

More Related Videos

Laboratory Estimation of Net Trophic Transfer Efficiencies of PCB Congeners to Lake Trout (Salvelinus namaycush) from Its Prey

Laboratory Estimation of Net Trophic Transfer Efficiencies of PCB Congeners to Lake Trout (Salvelinus namaycush) from Its Prey

Published on: August 29, 2014

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms

Published on: January 11, 2015

Related Experiment Videos

Last Updated: Jun 2, 2026

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

Laboratory Estimation of Net Trophic Transfer Efficiencies of PCB Congeners to Lake Trout (Salvelinus namaycush) from Its Prey

Laboratory Estimation of Net Trophic Transfer Efficiencies of PCB Congeners to Lake Trout (Salvelinus namaycush) from Its Prey

Published on: August 29, 2014

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms

Published on: January 11, 2015

Area of Science:

Environmental Toxicology
Ecotoxicology
Environmental Chemistry

Background:

Chemicals released into the environment can bioaccumulate in organisms, posing risks to individuals and food webs.
Predicting environmental bioaccumulation concentrations using laboratory data or chemical properties remains a significant challenge.
Discrepancies between laboratory bioaccumulation studies and field measurements are of scientific and regulatory concern.

Discussion:

A workshop convened scientists from academia, industry, and government to compare laboratory and field bioaccumulation data.
Five articles in this issue present workshop findings on assessing biomagnification, biota-sediment accumulation factors, and differences in bioaccumulation metrics.
Trophic magnification factors (TMFs) and their regulatory applications were also discussed.

Key Insights:

A weight-of-evidence approach using fugacity ratios can integrate field data into biomagnification assessments for legacy chemicals.
Direct comparisons reveal differences between laboratory and field bioaccumulation metrics for aquatic and terrestrial organisms.
Understanding TMF determination and interpretation is crucial for regulatory risk assessment.

Outlook:

Recommendations are provided to enhance the collection and interpretation of bioaccumulation data.
Improving the alignment between laboratory predictions and real-world bioaccumulation is essential for environmental protection.
Future research should focus on refining methods for assessing chemical risks in ecosystems.