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Synergism between resveratrol and other phytochemicals: implications for obesity and osteoporosis

Srujana Rayalam1, Mary Anne Della-Fera, Clifton A Baile

  • 1Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA.

Molecular Nutrition & Food Research
|May 4, 2011
PubMed

Insights

Resveratrol, a natural compound, reduces fat cell formation and boosts bone cell development. Combining it with other compounds may offer new therapies for obesity and osteoporosis.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Gerontology

Background:

  • Resveratrol, a phytoalexin, is known for its effects on sirtuins.
  • Its anti-cancer properties are well-studied, but its anti-adipogenic and osteogenic effects are gaining interest.
  • Resveratrol supplementation mimics caloric restriction, influencing lipid metabolism.

Purpose of the Study:

  • To investigate the effects of resveratrol on adipogenesis and osteogenesis.
  • To explore the inverse relationship between adipocytes and osteoblasts in bone marrow, particularly in aging populations.
  • To evaluate the synergistic effects of resveratrol with other phytochemicals.

Main Methods:

  • Studied resveratrol's effects on molecular targets in adipocytes and osteoblasts.
  • Investigated the impact of resveratrol combined with genistein and quercetin on adipogenesis in murine and human adipocytes.
  • Analyzed an in vivo study using phytochemicals including resveratrol and vitamin D in a postmenopausal rat model.

Main Results:

  • Resveratrol decreases adipocyte number and size while increasing osteogenesis.
  • Resveratrol, genistein, and quercetin synergistically reduced adipogenesis.
  • Phytochemical combinations prevented weight gain and bone loss in a rat model.

Conclusions:

  • Resveratrol influences mesenchymal stem cell differentiation, favoring osteogenesis over adipogenesis.
  • Combinations of resveratrol with other phytochemicals show promise for treating obesity and osteoporosis.
  • Further research into these combinations may lead to novel therapeutic strategies.

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