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Updated: Jun 2, 2026

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
Published on: July 23, 2016
Acid-degradable cationic dextran particles for the delivery of siRNA therapeutics
Jessica L Cohen1, Stephanie Schubert, Peter R Wich
1College of Chemistry, University of California, Berkeley, California 94720-1460, United States.
Abstract:
We report a new acid-sensitive, biocompatible, and biodegradable microparticulate delivery system, spermine modified acetalated-dextran (Spermine-Ac-DEX), which can be used to efficiently encapsulate siRNA. These particles demonstrated efficient gene knockdown in HeLa-luc cells with minimal toxicity. This knockdown was comparable to that obtained using Lipofectamine, a commercially available transfection reagent generally limited to in vitro use due to its high toxicity.
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