Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures ll: Types01:19

Seizures ll: Types

Seizures are sudden bursts of abnormal electrical discharge in the brain that interfere with normal function. They are commonly divided into three groups: focal seizures, generalized seizures, and other types that do not fit neatly into either category.Focal SeizuresFocal seizures begin in a single brain region. When awareness is preserved, they are called focal aware seizures and may cause sensations such as tingling, unusual smells, or flashing lights. When awareness is impaired, they are...
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Technical Feasibility of the Endoscopic Endonasal Approach for Clipping an Ophthalmic Artery Aneurysm With an Origin Lateral to the Optic Nerve: A Case Report.

Cureus·2026
Same author

Diagnostic value of stand-alone videos after inconclusive inpatient EEG-video monitoring.

Epilepsia·2026
Same author

Rapid EEG in Specific Clinical Situations.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same author

First reported case of abdominal Nocardia pseudocyst in the setting of a ventriculoperitoneal shunt: a case report and review of literature.

Journal of medical case reports·2025
Same author

A systematic review of the role of wearable devices and artificial intelligence applications in assessing functional outcomes after lumbar fusion.

The spine journal : official journal of the North American Spine Society·2025
Same author

Response to: Subclinical Epileptiform Discharge in Patients With Alzheimer Dementia: A Systematic Review and Meta-Analysis.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2025

Related Experiment Video

Updated: Jun 2, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

An update on epilepsy.

Mike R Schoenberg1, Alfred T Frontera, Ali Bozorg

  • 1Department of Psychiatry and Neurosciences, University of South Florida College of Medicine, 3515 E. Fletcher Ave., Tampa, FL 33613, USA. mschoenb@health.usf.edu

Expert Review of Neurotherapeutics
|May 5, 2011
PubMed
Summary

Advances in understanding epilepsy now integrate neurophysiology, neuroplasticity, and quality of life. New treatments and neurostimulation offer improved outcomes for seizure disorders.

More Related Videos

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

Ex Vivo Calcium Imaging for Drosophila Model of Epilepsy
04:41

Ex Vivo Calcium Imaging for Drosophila Model of Epilepsy

Published on: October 13, 2023

Related Experiment Videos

Last Updated: Jun 2, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

Ex Vivo Calcium Imaging for Drosophila Model of Epilepsy
04:41

Ex Vivo Calcium Imaging for Drosophila Model of Epilepsy

Published on: October 13, 2023

Area of Science:

  • Neurology
  • Neuroscience
  • Epileptology

Background:

  • Epilepsy understanding has advanced, integrating neurophysiology, neuroplasticity, sleep, neuropsychology, and social functioning.
  • Quality of life, education, and occupation are recognized as interacting factors in epilepsy management.
  • Recent updates cover status epilepticus, epilepsy in diverse populations (children, adults, women), and psychogenic nonepileptic seizures.

Framework:

  • Focus on untangling the complex interactions between new antiepileptic drugs and neurophysiological, neuropsychological, and behavioral outcomes.
  • Investigating the role of GABA in seizure pathophysiology to develop novel therapeutic strategies.
  • Utilizing neurostimulation technologies and neurosurgical procedures to improve clinical results and understand neuropathophysiology.

Implementation:

  • Neurostimulation enables unprecedented long-term in vivo electroneurophysiological recordings in specific human brain regions.
  • State-of-the-art updates were presented at the 64th Annual Meeting of the American Epilepsy Society and 3rd Biennial North American Regional Epilepsy Congress.
  • These advancements facilitate a deeper comprehension of brain plasticity in epilepsy.

Implications:

  • Improved clinical outcomes for patients with epilepsy through advanced treatments and surgical interventions.
  • Enhanced understanding of the neuropathophysiology of epilepsy and brain plasticity.
  • Integration of neurophysiological, neuropsychological, and behavioral aspects into comprehensive epilepsy care.