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Updated: Jun 2, 2026

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
Published on: July 17, 2012
Heat shock proteins protect against ischemia and inflammation through multiple mechanisms
Quinton Jones1, Tracy S Voegeli, Gefeng Li
1Laboratory of Molecular Neurobiology, Department of Anatomy and Neurobiology, Dalhousie University, 5850 College Street, Halifax, Nova Scotia B3H 4R2, Canada.
Abstract:
After heat shock or other metabolic stress, heat shock proteins (Hsps) are expressed at high levels in all tissues and cells. The highly inducible 70 kDa heat shock protein (Hsp70) is associated with improved post-ischemic myocardial contractile recovery. Similarly, the small 27 kDa heat shock protein (Hsp27), that is abundant in muscle, is also linked with improved myocardial function after ischemic injury. Various Hsps have pro-survival functions that include chaperone, anti-apoptotic and/or anti-inflammatory activity. In this review we will summarize our understanding of myocardial protection and present evidence for protection having time dependent aspects that appear to be stimulus dependent.
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