Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AEGIS reveals epitope- and clone-resolved convergence of CNS B and T cell autoreactivity in ROHHAD.

bioRxiv : the preprint server for biology·2026
Same author

Autoantibody landscapes in neurological Long COVID and post-COVID cognitive impairment show heterogeneity without a shared disease signature.

medRxiv : the preprint server for health sciences·2026
Same author

Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer's disease.

Signal transduction and targeted therapy·2026
Same author

Integrated proteomic and single-cell transcriptomic profiling elucidates immunomodulatory effects of L-serine in autism spectrum disorder.

Scientific reports·2026
Same author

Structure-guided design of a targeted autoantibody degrader for neurologic disease.

bioRxiv : the preprint server for biology·2026
Same author

Anti-CD320 Autoantibodies and Central Nervous System Vitamin B12 Deficiency in Idiopathic Myelopathy.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Jun 2, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

Wnt5a controls neurite development in olfactory bulb interneurons.

Darya Pino1, Youngshik Choe, Samuel J Pleasure

  • 1Department of Neurology, University of California, San Francisco, CA, U.S.A.

ASN Neuro
|May 5, 2011
PubMed
Summary

Wnt5a

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Postnatal neurogenesis in the subventricular zone (SVZ) generates interneurons for the olfactory bulb (OB).
  • Developing OB interneurons migrate extensively while maintaining an immature morphology.
  • The molecular mechanisms regulating this morphological development are not fully understood.

Purpose of the Study:

  • To investigate the role of the Wnt signaling pathway in the morphological development of olfactory bulb interneurons.
  • To determine the specific Wnt pathway (canonical vs. non-canonical) involved in regulating interneuron maturation during migration.

Main Methods:

  • In vitro studies using neural precursors from the SVZ.
  • In vivo studies examining OB interneuron development.

More Related Videos

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo
08:29

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo

Published on: October 30, 2014

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow
14:33

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow

Published on: May 6, 2010

Related Experiment Videos

Last Updated: Jun 2, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo
08:29

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo

Published on: October 30, 2014

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow
14:33

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow

Published on: May 6, 2010

  • Analysis of Wnt5a-induced non-canonical Wnt signaling.

    • Main Results:

    • Non-canonical Wnt signaling, induced by Wnt5a, is crucial for the morphological development of OB interneurons.
    • Non-canonical Wnt signaling opposes canonical Wnt signaling in SVZ neural precursors.
    • Wnt5a plays a significant role in regulating dendrite maturation in OB interneurons.

    Conclusions:

    • Wnt5a-induced non-canonical Wnt pathway is essential for OB interneuron morphological development.
    • Canonical and non-canonical Wnt pathways act antagonistically in regulating dendrite maturation.
    • This study reveals a novel function for Wnt5a in olfactory bulb interneuron development.