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Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases
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A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

Published on: February 21, 2015

Neural tissue engineering using embryonic and induced pluripotent stem cells.

Stephanie M Willerth1

  • 1Department of Mechanical Engineering, University of Victoria, PO Box 3055, STN CSC, Victoria, British Columbia, V8W 3P6 Canada. willerth@uvic.ca

Stem Cell Research & Therapy
|May 5, 2011
PubMed
Summary

Human embryonic stem cells offer potential for neural tissue engineering in central nervous system disorders. Induced pluripotent stem cells present a promising alternative for regenerative therapies.

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Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies
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Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons
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Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies
12:13

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Published on: July 11, 2019

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Human embryonic stem cells (hESCs) possess pluripotency, enabling differentiation into diverse neural cell types.
  • Acute spinal cord injury is a focus for new hESC-derived therapies entering clinical trials.
  • Central nervous system (CNS) diseases and disorders represent a significant area for neural tissue engineering.

Purpose of the Study:

  • To review literature on hESC applications in neural tissue engineering for CNS conditions.
  • To evaluate the potential of induced pluripotent stem cells (iPSCs) as an alternative to hESCs.
  • To discuss methods for directing hESC differentiation into specific neural phenotypes.

Main Methods:

  • Literature review of studies utilizing embryonic stem cells for CNS tissue replication.
  • Analysis of differentiation strategies employing various cues to guide neural cell development.
  • Assessment of research on iPSCs for neural regenerative applications.

Main Results:

  • hESCs can be directed to differentiate into various neural cell types.
  • Multiple studies explore hESC-based approaches for repairing damaged neural tissue.
  • iPSCs offer a viable alternative, potentially overcoming some hESC limitations.

Conclusions:

  • hESCs show significant promise for neural tissue engineering in CNS disorders.
  • Directed differentiation protocols are advancing the therapeutic potential of hESCs.
  • iPSCs represent an important emerging option for regenerative therapies in neurology.