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Related Experiment Videos

Persistent metronidazole-induced peripheral neuropathy.

E G Boyce1, E T Cookson, W S Bond

  • 1Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy and Science, PA 19104.

DICP : the Annals of Pharmacotherapy
|January 1, 1990
PubMed
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Metronidazole, an antibiotic, can cause peripheral neuropathy, a debilitating nerve condition. This case highlights the importance of monitoring neurological health in Crohn

Area of Science:

  • Neurology
  • Gastroenterology
  • Pharmacology

Background:

  • Crohn's disease is a chronic inflammatory bowel condition.
  • Metronidazole is a commonly prescribed antibiotic for various infections.

Observation:

  • A young woman with Crohn's disease developed severe peripheral neuropathy.
  • Symptoms emerged after 50 days of metronidazole treatment (2000 mg/d).

Findings:

  • Peripheral neuropathy significantly improved after metronidazole discontinuation.
  • Neuropathy symptoms persisted for at least two years post-treatment.

Implications:

  • This case underscores the potential neurotoxic effects of metronidazole.
  • Close neurologic monitoring is crucial for patients on long-term metronidazole therapy.

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