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Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Protective and ultra-protective ventilation: using pumpless interventional lung assist (iLA)
1Department Anaesthesiology, Emergency and Critical Care Medicine, Georg-August-University of Göttingen, Göttingen, Germany. omoerer@gwdg.de
Minerva Anestesiologica
|May 5, 2011
Summary
Pumpless interventional lung assist (iLA) offers efficient carbon dioxide removal, enabling ultraprotective mechanical ventilation. This approach may reduce complications and improve outcomes for patients with acute respiratory failure.
Area of Science:
- Pulmonology
- Critical Care Medicine
- Biomedical Engineering
Background:
- Acute lung failure carries high mortality, often necessitating mechanical ventilation.
- Mechanical ventilation can cause complications and worsen lung conditions, increasing morbidity and mortality.
- Extracorporeal gas exchange is an alternative when conventional ventilation fails.
Purpose of the Study:
- To review the current status of pumpless extracorporeal interventional lung assist (iLA).
- To explore the potential role of iLA in lung-protective ventilation strategies.
- To highlight iLA's efficacy in carbon dioxide removal and enabling reduced ventilator settings.
Main Methods:
- Review of current literature on pumpless extracorporeal interventional lung assist (iLA).
- Analysis of iLA's application via an arterio-venous bypass with an integrated gas exchange membrane.
- Comparison with veno-venous extracorporeal membrane oxygenation (ECMO).
Main Results:
- iLA facilitates efficient carbon dioxide removal.
- iLA allows for significant reduction in mechanical ventilator settings.
- iLA enables ultraprotective ventilation with very low tidal volumes.
Conclusions:
- Pumpless iLA is a valuable tool for managing acute respiratory failure.
- iLA supports lung-protective and ultraprotective ventilation strategies.
- iLA may mitigate complications associated with conventional mechanical ventilation.
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