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Related Concept Videos

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Allosteric Proteins-ATCase01:19

Allosteric Proteins-ATCase

Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis pathway,...
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
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Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...
Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...

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The case for locus-specific databases.

Mark E Samuels1, Guy A Rouleau

  • 1Ste-Justine Hospital Research Center and Department of Medicine, University of Montreal, 3175 Cote Ste-Catherine, Montreal, Quebec, Canada.

Nature Reviews. Genetics
|May 5, 2011
PubMed
Summary
This summary is machine-generated.

Locus-specific databases are essential for understanding medical genetic conditions. Continued support is crucial for maintaining these vital genetic sequence information resources.

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Area of Science:

  • Genetics
  • Bioinformatics
  • Medical Genetics

Background:

  • Locus-specific databases (LSDBs) are critical resources in medical genetics.
  • They house sequence information pertinent to human genetic disorders.
  • The maintenance and accessibility of LSDBs are paramount for research and clinical applications.

Purpose of the Study:

  • To emphasize the indispensable role of LSDBs in medical genetics.
  • To advocate for sustained support and resources for these databases.

Main Methods:

  • This study is a perspective piece, not involving empirical data collection.
  • It relies on the established importance and utility of existing LSDBs.

Main Results:

  • LSDBs are uniquely valuable repositories for genetic condition data.
  • Their continued existence is directly linked to ongoing support and funding.

Conclusions:

  • Sustained support for locus-specific databases is essential for advancing the study of medical genetic conditions.
  • These databases represent a cornerstone of genetic information management and require community backing.