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Related Concept Videos

Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...

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Related Experiment Video

Updated: Jun 2, 2026

Nuclear Migration in the Drosophila Oocyte
04:17

Nuclear Migration in the Drosophila Oocyte

Published on: May 13, 2021

Interkinetic nuclear migration: cell cycle on the move.

Filippo Del Bene1

  • 1Centre de Recherche, Institut Curie, Paris, France. filippo.del-bene@curie.fr

The EMBO Journal
|May 5, 2011
PubMed
Summary

Interkinetic nuclear migration (INM) involves cell nuclei moving with the cell cycle in developing brains. A new study reveals the protein Tpx2 links nuclear movement to cell division by organizing microtubules.

Area of Science:

  • Cell biology
  • Developmental biology
  • Neuroscience

Background:

  • Interkinetic nuclear migration (INM) is a crucial process in developing neuroepithelia.
  • INM involves periodic movement of the cell nucleus synchronized with cell-cycle progression.

Discussion:

  • Kosodo et al. elucidate a molecular mechanism connecting nuclear migration and the cell cycle.
  • The microtubule-associated protein Tpx2 plays a key role in this process.

Key Insights:

  • Tpx2 redistributes from the nucleus to the apical process during the S-G2 phase transition.
  • This redistribution modulates microtubule organization, driving apical nuclear migration.

Outlook:

  • Understanding Tpx2's role provides insights into neurodevelopmental processes.

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Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
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Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

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Last Updated: Jun 2, 2026

Nuclear Migration in the Drosophila Oocyte
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  • Further research can explore therapeutic targets for developmental disorders affecting neuroepithelia.