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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

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Published on: June 7, 2019

Acral lentiginous melanoma: a case control study and guidelines update.

Christoforos Kosmidis¹, Christoforos Efthimiadis, Georgios Anthimidis

¹Department of Surgery, Interbalkan European Medical Center, 84 Tsimiski Street, 54622 Thessaloniki, Greece.

Case Reports in Medicine

|May 5, 2011

Summary

This case report details a rare acral lentiginous melanoma on the foot. Successful management involved wide local excision and skin grafting, with no recurrence observed during follow-up.

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Area of Science:

Dermatology
Oncology

Background:

Malignant melanoma incidence is rising globally.
Acral lentiginous melanoma (ALM) is a rare subtype, often presenting on the soles or palms.
Early diagnosis and management are crucial for patient outcomes.

Observation:

A 58-year-old male presented with a suspicious lesion on his right foot sole.
The lesion measured 15-20 mm in diameter.
Initial biopsy confirmed acral lentiginous melanoma.

Findings:

Histopathological diagnosis confirmed ALM.
Sentinel lymph node biopsy revealed no micrometastases (AJCC Stage IB: T2aN0M0).
Wide local excision (2 cm margin) and split-thickness skin grafting were performed for reconstruction.

Implications:

This case highlights the importance of recognizing rare melanoma subtypes.
Effective surgical management, including wide excision and reconstruction, can lead to favorable outcomes.
Further research into optimal ALM management strategies is warranted.