Related Experiment Video

Updated: Jun 2, 2026

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
11:48

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes

Published on: May 31, 2018

Immunologic monitoring of cellular responses by dendritic/tumor cell fusion vaccines

Shigeo Koido1, Sadamu Homma, Akitaka Takahara

  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. shigeo_koido@jikei.ac.jp

Journal of Biomedicine & Biotechnology
|May 5, 2011
PubMed

Insights

Dendritic cell (DC)-based cancer vaccines show promise in preclinical studies but limited clinical success. Evaluating these vaccines requires immunologic monitoring beyond standard tumor response criteria.

Area of Science:

  • Immunology
  • Oncology
  • Vaccinology

Background:

  • Dendritic cell (DC)-based cancer vaccines demonstrate potent antitumor activity in preclinical models.
  • Clinical translation of DC-based cancer vaccines has yielded limited therapeutic success.
  • Current RECIST and WHO criteria may not fully capture the immune-mediated effects of cancer vaccines.

Purpose of the Study:

  • To review immunologic monitoring strategies for evaluating cancer vaccines.
  • To highlight the limitations of standard tumor response criteria for assessing vaccine efficacy.
  • To discuss the role of cellular immune monitoring in the rational development of DC-based cancer vaccines.

Main Methods:

  • Review of existing literature on cancer vaccine evaluation.
  • Discussion of immunologic monitoring techniques for cellular responses.
  • Analysis of the applicability of RECIST and WHO criteria to cancer vaccines.

Main Results:

  • Standard tumor response criteria may not adequately assess cancer vaccine efficacy.
  • Immunologic monitoring of cellular responses is crucial for vaccine development.
  • DC-DC fusions and whole tumor cell vaccines require specific evaluation methods.

Conclusions:

  • Rethinking evaluation metrics is necessary for advancing cancer vaccine therapy.
  • Integrating immunologic monitoring with clinical assessment will improve vaccine development.
  • Cellular immune monitoring is essential for understanding and optimizing cancer vaccine outcomes.

More Related Videos

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination11:07

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Vaccinations01:51

Vaccinations

Overview
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...