Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sequential decrease in platelet energy charge after hepatic resection in cirrhotics.

M Zaima1, M Noguchi, Y Wada

  • 1Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.

American Journal of Surgery
|February 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Seasonal fluctuations of substance P and vasoactive intestinal peptide concentrations in nasal secretions of patients with nasal allergy to Japanese cedar pollen].

Arerugi = [Allergy]·1992
Same author

Argyrophilic nucleolar organizer region counts in exocrine pancreatic tumors.

International journal of pancreatology : official journal of the International Association of Pancreatology·1992
Same author

Investigation and research on classification of productive skills (1)--Actual work and skills in the car manufacturing industry.

Journal of human ergology·1992
Same author

The usefulness of intraoperative drip infusion cholangiography during laparoscopic cholecystectomy.

Surgical laparoscopy & endoscopy·1992
Same author

Analyses of the risk and operative stress for donors in living-related partial liver transplantation.

Transplantation·1992
Same author

Coding of odor molecules by mitral/tufted cells in rabbit olfactory bulb. I. Aliphatic compounds.

Journal of neurophysiology·1992

Platelet energy metabolism is impaired in cirrhotic patients after liver surgery, indicated by decreased adenylate energy charge. This suggests activated platelets and damaged function, even without overt clotting signs.

Area of Science:

  • Biochemistry
  • Hematology
  • Surgical Research

Background:

  • Hepatic resection can impact patient metabolic status.
  • Platelet function is crucial in surgical recovery and hemostasis.
  • Cirrhosis affects systemic metabolic processes and organ function.

Purpose of the Study:

  • To evaluate the metabolic status of human platelets in the early postoperative period following hepatic resection.
  • To compare platelet adenylate energy charge between cirrhotic and noncirrhotic patients post-surgery.

Main Methods:

  • Measurement of adenylate energy charge in human platelets.
  • Analysis of platelet metabolic markers including adenosine triphosphate and hypoxanthine.
  • Comparison of metabolic parameters in cirrhotic versus noncirrhotic patients in the early postoperative phase.

Related Experiment Videos

Main Results:

  • A significant decrease in platelet adenylate energy charge was observed in cirrhotic patients on postoperative days 1-3.
  • Noncirrhotic patients did not exhibit a significant decrease in platelet adenylate energy charge.
  • Decreased adenosine triphosphate and increased hypoxanthine levels correlated with reduced adenylate energy charge in cirrhotic patients.

Conclusions:

  • Cirrhotic patients experience impaired platelet energy metabolism post-hepatic resection.
  • Intravascular platelet activation and functional damage occur in cirrhotic patients after surgery.
  • These platelet changes are present even in the absence of clinical evidence of disseminated intravascular coagulation.