Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mechanisms of Retrovirus-induced Cancers

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...

Mechanisms of Retrovirus-induced Cancers

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reflectance confocal microscopy in lentigo maligna and lentigo maligna melanoma: a state-of-the-art overview.

Annales de dermatologie et de venereologie·2026

Same author

Concordance of pathologic response assessment between local and central review in melanoma: a post hoc analysis of KEYMAKER-U02 substudy 02C.

ESMO open·2026

Same author

Muir-Torre syndrome revealed by sebaceous carcinoma of the scrotum.

Annales de dermatologie et de venereologie·2025

Same author

Immune checkpoint inhibitors induced subcutaneous panniculitis-like T-cell lymphoma.

Annales de dermatologie et de venereologie·2025

Same author

Efficacy of adjuvant therapy in patients with stage IIIA cutaneous melanoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2025

Same author

Corrigendum to "Moderate physical activity during neoadjuvant chemotherapy in breast cancer patients: effect on cancer-related inflammation and pathological complete response-the Neo-Runner study": [ESMO Open 9 (2024) 10.1016/j.esmoop.2024.103665].

ESMO open·2024

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Isolation, Transfection, and Culture of Primary Human Monocytes

Isolation, Transfection, and Culture of Primary Human Monocytes

Published on: December 16, 2019

Oncogenesis in HIV-infection.

A Albini¹, M Aluigi, R Benelli

¹UNIV MILAN,DERMATOL CLIN 1,I-20157 MILAN,ITALY. KAROLINSKA HOSP & INST,IMMUNOPATHOL LAB,S-17176 STOCKHOLM,SWEDEN. MAX PLANCK INST BIOCHEM,ABT VIRUSFORSCH,D-82152 MARTINSRIED,GERMANY. UNIV PADUA,IST ONCOL,I-35128 PADUA,ITALY. HOP ST LOUIS,F-75010 PARIS,FRANCE. UNIV ERLANGEN NURNBERG,INST KLIN & MOLEK VIROL,D-91054 ERLANGEN,GERMANY. L SACCO HOSP VIALBA,DEPT PATHOL,I-20157 MILAN,ITALY. IST NAZL RIC CANC,LAB ONCOL MED,I-16132 GENOA,ITALY. KAROLINSKA HOSP & INST,NEUROGENET LAB,S-17176 STOCKHOLM,SWEDEN. UNIV VIENNA,SCH MED,DEPT DERMATOL,DIV IMMUNOL ALLERGY & INFECT DIS,A-1090 VIENNA,AUSTRIA.

International Journal of Oncology

|May 5, 2011

Summary

Human Kaposi

More Related Videos

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Published on: January 5, 2016

Related Experiment Videos

Last Updated: Jun 2, 2026

Isolation, Transfection, and Culture of Primary Human Monocytes

Isolation, Transfection, and Culture of Primary Human Monocytes

Published on: December 16, 2019

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Published on: January 5, 2016

Area of Science:

Virology
Oncology
Dermatology

Background:

Kaposi's sarcoma (KS) is a complex malignancy with diverse epidemiological presentations.
The role of human Kaposi's sarcoma associated herpesvirus-like virus (KSHV) in KS pathogenesis requires further investigation across different KS variants.

Purpose of the Study:

To investigate the presence and association of KSHV in various epidemiological subtypes of Kaposi's sarcoma.
To evaluate KSHV detection in KS-derived cell cultures for potential research applications.

Main Methods:

Polymerase chain reaction (PCR) was employed to detect KSHV DNA.
Analysis included tumor biopsies from AIDS-associated, endemic, sporadic, and post-transplant KS.
KSHV detection was also assessed in non-involved skin, peripheral blood mononuclear cells, lymphoma biopsies, and KS-derived cell cultures.

Main Results:

KSHV DNA was detected in all examined KS tumor biopsies across all epidemiological variants.
KSHV sequences were rarely found in non-KS tissues and peripheral blood.
While initially transient, long-term KSHV-positive KS-derived cell cultures were established from sporadic and epidemic KS biopsies.

Conclusions:

A strong association between KSHV and Kaposi's sarcoma tissue is confirmed across all epidemiological variants.
Long-term KSHV-positive KS cell cultures represent a valuable resource for studying KSHV's role in KS initiation and progression.