Related Experiment Video
Updated: Jun 2, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
Human papillomaviruses (HPV) are associated with multiple myeloma
1UNIV TEXAS,MED BRANCH,DEPT MICROBIOL,GALVESTON,TX 77555. UNIV TEXAS,MED BRANCH,DEPT DERMATOL,GALVESTON,TX 77555. UNIV TEXAS,MED BRANCH,DEPT INTERNAL MED,GALVESTON,TX 77555. UNIV TEXAS,MED BRANCH,DEPT PATHOL,GALVESTON,TX 77555. BAYLOR COLL MED,DEPT NEUROL,HOUSTON,TX 77030.
Abstract:
Human papillomaviruses (HPV) are small DNA tumor viruses, and are associated with epithelial neoplasias. Although HPV are believed to be exclusively permissive in terminally differentiated squamous cells, we have previously identified HPV sequences in lymphoid tissues of five patients. Because this result suggested that the range of the host virus cells could include cells of lymphoid origin, we used PCR and in situ hybridization to analyze nonepithelial tissues of patients with multiple myeloma from two institutions. A statistically significant association was established between HPV and multiple myeloma (p<0.001). This study supports the hypothesis that HPV can infect lymphoid cells.
Related Concept Videos
Mechanisms of Retrovirus-induced Cancers
Mechanisms of Retrovirus-induced Cancers
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Induced Pluripotent Stem Cells
Somatic cells are...
Cancer Prevention
Some...
