[The impact of prior revascularization procedures on outcome of percutaneous coronary intervention in ACS]
Wojciech Walkowicz1, Zbigniew Gasior, Józefa Dabek
1Slaski Uniwersytet Medyczny w Katowicach, Katedra i Klinika Kardiologii.
Insights
Patients with prior revascularization undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) have more risk factors and advanced disease. Outcomes are similar, but hospitalization is longer for these patients.
Area of Science:
- Interventional Cardiology
- Cardiovascular Medicine
- Clinical Research
Context:
- The increasing prevalence of interventional cardiology has led to a growing number of acute coronary syndrome (ACS) patients with a history of revascularization procedures.
- Understanding the unique clinical features and outcomes of these patients is crucial for optimizing treatment strategies.
Purpose:
- To evaluate the clinical characteristics of ACS patients with and without prior revascularization.
- To compare in-hospital and long-term outcomes following percutaneous coronary intervention (PCI) in these distinct patient groups.
Summary:
- A study of 325 ACS patients undergoing PCI found that those with prior revascularization (n=175) exhibited higher rates of heart failure, diabetes, and multi-vessel coronary disease compared to controls (n=150).
- Previously revascularized patients also showed a higher incidence of non-ST-elevation myocardial infarction (NSTEMI) and a longer hospital stay, although 6-month clinical outcomes were comparable.
- These findings highlight that while PCI outcomes are similar, patients with prior revascularization present with more complex disease profiles.
Impact:
- This research provides valuable insights into the management of ACS patients with prior revascularization, informing clinical decision-making and resource allocation.
- The study underscores the need for tailored approaches in managing complex cardiovascular disease in patients with a history of interventions.
- Results contribute to the body of evidence guiding the application of PCI in a growing patient population with complex coronary artery disease.
Unlabelled:
Development of interventional cadriology is cause of increasing number of acute coronary syndrome (ACS) patients with prior revascularization procedures in the past.
The Aim Of The Study:
To evaluate the clinical feature of ACS patients with and without prior revascularization procedures and to compare in-hospital and long-term outcome following percutaneous coronary intervention (PCI) in these groups.
Material And Methods:
There were 325 ACS consecutive patients included to the study who underwent PCI procedures. There were 175 patients after PCI or coronary artery by-pass grafting in the past. Control group consisted of 150 subjects with ACS with no history of PCI procedures. We analyzed baseline characteristic as well as the inhospital, 30- and 180-day outcomes.
Results:
The baseline characteristic revealed higher rate of patients with heart failure in case-history (18.0% vs. 26.9%, p = 0.03), diabetes (16.0% vs. 25.1%, p = 0.04), and multi-vessels coronary disease (85.2% vs. 60.6%, p = 0.003) in the subgroup of prior revascularization. The rate of non-STEMI was higher (28.0% vs. 40.6%, p = 0.02) and the rate of STEMI was lower (47.4% vs. 63.3%, p = 0.004) as a form of ACS in previously revascularized subjects. The analysis of inhospital outcome revealed significantly longer time of hospitalization of the patients with prior revascularization (7.7 +/- 4.6 vs. 5.4 +/- 4.1, p < 0.0001). There were no significant differences in clinical characteristics at 6-months after ACS.
Conclusion:
Patients undergoing PCI in ACS with prior revascularization procedures are characterized by a higher level of atherosclerosis risk factors, more advanced changes in coronary arteries and higher NSTEMI occurance than ACS patients without PCI history. Baseline and long-term results of revascularization, frequency and nature of complications are comparable in both groups, but length of hospitalization period and significantly longer in patients with revascularization in the past.
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