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Updated: Jun 2, 2026

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
Published on: December 5, 2020
[Study of a novel compound 2460A with activities produced by fungus]
Xiao-qiang Qi1, Feng-chang Zhu, Yang Zhang
1Ministry of Health Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences & Peking Union Medical College, Bejing 100050, China.
Abstract:
With IL-6R as target, a new compound 2460A was identified from fungus using HTS screening model. The taxonomics of the produced strain was confirmed to be Trichoderma hazianum rifai after sequencing analysis of rDNA-ITS (internal transcribed spacer). Results showed that this compound has a binding activity on IL-6R competed with IL-6, thus it is a new ligand of IL-6R originating from microbe. With MTT assay, the anti-tumor activities of 2460A were demonstrated on CM126 and HT-29 cell lines separately, the IC50 are 2.17 x 10(-5) mol x L(-1) and 1.8 x 10(-5) mol x L(-1) respectively. The compound affected lightly the HT-29 cell cycle at S phase. Studies for the anti-tumor activity of 2460A in vivo are in progress in our lab.
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