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Interleukin 10 and residual kidney function are associated with risk of vascular calcification in patients undergoing

C-T Lee1, Y-C Tsai, C-Y Su

  • 1Division of Nephrology, Department of Internal Medicine, Chang-Gung Memorial Hospital, Niao-Sung Shang, Kaohsiung, Taiwan. ctlee33@adm.cgmh.org.tw

Clinical Nephrology
|May 6, 2011
PubMed

Insights

Vascular calcification in peritoneal dialysis (PD) patients is linked to age, PD duration, and body mass index. Interleukin-10 (IL-10) and residual kidney function (RKF) are also key factors in PD vascular calcification.

Area of Science:

  • Nephrology
  • Cardiovascular Health
  • Medical Imaging

Background:

  • Vascular calcification is a frequent complication in dialysis patients.
  • The pathogenesis of vascular calcification is multifactorial.
  • The roles of pro-inflammatory cytokines and residual kidney function (RKF) in peritoneal dialysis (PD) patients with vascular calcification remain under-investigated.

Purpose of the Study:

  • To investigate the association of pro-inflammatory cytokines and RKF with vascular calcification in PD patients.
  • To identify independent risk factors for vascular calcification in PD patients.

Main Methods:

  • 157 stable PD patients underwent plain X-ray examinations (chest and pelvis).
  • Vascular calcification was assessed on X-rays.
  • Biochemical data, pro-inflammatory markers (including IL-10), and PD-related factors were collected.

Main Results:

  • Vascular calcification prevalence was 38.2% in chest X-rays and 22.3% in pelvis films.
  • Independent factors associated with vascular calcification in chest X-rays included age, PD duration, BMI, and RKF.
  • Factors associated with calcification in pelvis films were age, diabetes, IL-10, and RKF. Age, PD duration, diabetes, IL-10, and RKF were independently related to calcification in both imaging sites.

Conclusions:

  • Interleukin-10 (IL-10) and residual kidney function (RKF) are significant factors associated with vascular calcification in PD patients.
  • These findings highlight novel targets for managing vascular complications in PD.
Abstract

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