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Updated: Jun 2, 2026
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Proton beam therapy for hepatocellular carcinoma located adjacent to the alimentary tract
Hidetsugu Nakayama1, Shinji Sugahara, Kuniaki Fukuda
1Department of Radiation Oncology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Purpose:
To evaluate the safety and effectiveness of proton beam therapy for hepatocellular carcinoma (HCC) located adjacent to the alimentary tract.
Patients And Methods:
Forty-seven patients (median age, 69 years; range, 43-82 years) who had HCC located within 2 cm of the alimentary tract underwent proton beam therapy. Liver damage according to the Child-Pugh classification was Class A in 35 patients, Class B in 9, and Class C in 3. Treatment protocols of the early 16 patients and the late 31 patients were 72.6 GyE in 22 fractions and 77 GyE in 35 fractions, respectively.
Results:
During the median follow-up period of 23 months, 24 patients died; the remaining 23 patients were alive until September 2008. The median overall survival was 33.9 months (95% confidence interval [CI], 10.8-57.0 months). Actuarial overall and local progression-free survival rates at 3 years were 50.0% and 88.1%, respectively. Grade 2 and 3 alimentary tract hemorrhage was observed in 3 (6.4%) and 1 (2.1%) patients, respectively.
Conclusions:
Our proton beam therapy strategy for HCC located adjacent to the alimentary tract seems to be effective but should be performed with caution.
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