Related Experiment Video
Updated: Jun 2, 2026

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
Published on: November 11, 2018
Signaling pathways regulated by Rho-like proteins
Abstract:
Small GTP-binding proteins of the Rho-subfamily, including Cdc42, Rac1 and RhoA, are key control molecules in the reorganization of the actin cytoskeleton induced by growth factors. Recent studies indicate that signal transduction pathways regulated by Rho-like GTPases are interconnected with the Ras-Raf-MAPkinase pathway, and play a role in several kinase pathways that lead to transcriptional activation and oncogenic transformation. Moreover, pathways regulated by Rac are involved in the acquisition of invasive and metastatic capacity of tumor cells. Aberrations in signaling pathways controlled by Rho-like GTPases may thus have consequences for tumor progression and metastasis.
More Related Videos
Related Concept Videos
Small GTPases - Ras and Rho
Three regulatory proteins control their activity:
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Amplifying Signals via Enzymatic Cascade
Amplifying Signals via Second Messengers
Assembly of Signaling Complexes
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
MAPK Signaling Cascades
