Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Urine Studies I: Urinalysis

Urine Studies I: Urinalysis

Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...

Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

Imaging Studies IV: Magnetic Resonance Imaging

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...

Serum Studies: Renal Function Tests

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.

Nursing Assessment of the Genitourinary System I: Health History

Nursing Assessment of the Genitourinary System I: Health History

The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Facile synthesis of Co<sub>3</sub>Te<sub>4</sub>-Fe<sub>3</sub>C for efficient overall water-splitting in an alkaline medium.

Nanoscale advances·2025

Same author

Thermoelectric Properties of CrS<sub>2-</sub> Te <sub></sub> (<i>x</i>: 0, 1, 2) Dichalcogenides Monolayers: First-Principles Study.

ACS omega·2024

Same author

Leave events among Aboriginal and Torres Strait Islander people: a systematic review.

BMC public health·2022

Same author

Geology of the InSight landing site on Mars.

Nature communications·2020

Same author

The Seismic Signatures of Recently Formed Impact Craters on Mars.

Journal of geophysical research. Planets·2020

Same author

Artificial intelligence for the real-time classification of intrapapillary capillary loop patterns in the endoscopic diagnosis of early oesophageal squamous cell carcinoma: A proof-of-concept study.

United European gastroenterology journal·2019

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Urinary markers for prostate cancer.

M Abdul¹, M Banks, N Hoosein

¹UNIV TEXAS,MD ANDERSON CANC CTR,DEPT GENITOURINARY MED ONCOL,HOUSTON,TX 77030.

International Journal of Oncology

|May 6, 2011

Summary

Elevated urinary immunoglobulins (Igs), bombesin-like immunoreactivity (BLI), and beta-2 microglobulin (beta-2m) are frequent in advanced prostate cancer and linked to shorter survival. These urine markers show potential for cancer detection and prognosis.

Area of Science:

Urology
Oncology
Biochemistry

Background:

Advanced prostate cancer diagnosis and prognosis remain critical challenges in urologic oncology.
Biomarkers for non-invasively monitoring disease progression and predicting patient outcomes are highly sought after.

Purpose of the Study:

To investigate the frequency and prognostic significance of specific urinary biomarkers in patients with advanced prostate cancer.
To assess the correlation of these urinary markers with established serum markers.

Main Methods:

Radioimmunoassay was employed to measure urinary levels of immunoglobulins (Igs), bombesin-like immunoreactivity (BLI), beta-2 microglobulin (beta-2m), and transferrin.
Measurements were taken from the first voided urine of 40 patients with advanced prostate adenocarcinoma.

More Related Videos

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

Cell-Free DNA Integrity Analysis in Urine Samples

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

Related Experiment Videos

Last Updated: Jun 2, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

Cell-Free DNA Integrity Analysis in Urine Samples

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

Urinary marker levels were compared to those of 16 age-matched healthy controls and correlated with serum chromogranin A and prostate-specific antigen (PSA).

Main Results:

Elevated urinary Igs (48%), BLI (30%), beta-2m (74%), and transferrin (20%) were observed in patients with advanced prostate cancer compared to controls.
Higher levels of urinary Igs, BLI, or beta-2m were significantly associated with shorter patient survival.
The four urinary markers demonstrated a good correlation with serum chromogranin A but not with serum PSA.

Conclusions:

Urinary Igs, BLI, beta-2m, and transferrin are frequently elevated in advanced prostate cancer.
Urinary beta-2 microglobulin and immunoglobulins show particular promise as prognostic indicators.
These urinary biomarkers may offer a valuable, non-invasive tool for assessing disease status and predicting outcomes in advanced prostate cancer.