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Urinary Bladder

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...

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Updated: Jun 2, 2026

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Published on: May 29, 2015

HER-2/neu in bladder carcinoma.

S Tommasi¹, P Ditonno, M Sisto

¹POLICLIN BARI,DEPT UROL,BARI,ITALY. UNIV BARI,INST PATHOL,BARI,ITALY.

International Journal of Oncology

|May 6, 2011

Summary

This summary is machine-generated.

This study found no significant link between HER-2/neu gene alterations and bladder cancer outcomes like recurrence or survival. HER-2/neu status did not predict patient prognosis in the studied cohort.

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Area of Science:

Oncology
Molecular Biology
Genetics

Background:

The HER-2/neu gene is implicated in various cancers.
Understanding its role in bladder cancer is crucial for prognosis.

Purpose of the Study:

To investigate the relationship between HER-2/neu gene alterations (amplification and overexpression) and clinicopathological features in bladder cancer.
To determine if HER-2/neu status can identify a subgroup of patients with poor prognosis regarding recurrence, progression, and survival.

Main Methods:

Analysis of HER-2/neu DNA amplification and protein overexpression in 66 bladder cancer patients using Southern and Western blot techniques.
Statistical evaluation of findings in relation to pathological staging, tumor grading, tumor multiplicity, and clinical outcomes.

Main Results:

HER-2/neu amplification was observed in 13% and overexpression in 39% of cases.
No significant association was found between HER-2/neu alterations and pathological staging or tumor grading.
Multifocal tumors showed a higher prevalence of HER-2/neu amplification and overexpression compared to monofocal tumors.
Statistical analyses revealed no significant correlation between HER-2/neu amplification/overexpression and clinical outcomes such as time to recurrence, time to progression, or survival.

Conclusions:

HER-2/neu gene alterations are not significantly associated with pathological characteristics in bladder cancer.
HER-2/neu status does not appear to be a reliable predictor of tumor relapse, progression, or patient survival in bladder cancer.