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Related Concept Videos

Viral Meningitis01:18

Viral Meningitis

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Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
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Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

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Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect...
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Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

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Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
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Encephalitis l: Introduction01:19

Encephalitis l: Introduction

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Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
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Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

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Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
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Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

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A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial...
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Related Experiment Video

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Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
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Post-infectious headache: a reactive headache?

Sanjay Prakash1, Niyati Patel, Purva Golwala

  • 1Department of Neurology, Medical College, SSG Hospital, O-19, Doctor's Quarter, Jail Road, Baroda 390001, Gujarat, India. drprakashs@yahoo.co.in

The Journal of Headache and Pain
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Summary
This summary is machine-generated.

Post-infectious headache, a daily headache lasting 1-4 weeks, is often overlooked. Early treatment may prevent chronic symptoms, with steroids showing good response in some cases.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Headache Medicine

Background:

  • Post-infectious disease syndrome encompasses various neurological and non-neurological disorders.
  • Headache as an isolated or presenting complaint of post-infectious illness is underrecognized in medical literature.

Purpose of the Study:

  • To investigate clinical features and therapeutic responses in patients with daily headaches.
  • To compare patients with a history of recent febrile illness versus those without.

Main Methods:

  • Retrospective observational study.
  • Inclusion criteria: daily headache >1 week and <4 weeks duration.
  • Comparison of clinical features and drug responses between patients with and without preceding febrile illness.

Main Results:

  • No significant demographic differences between groups.
  • Increased prevalence of neck pain, nausea, photophobia, and meningeal signs in the post-infectious headache group.
  • Lower complete response rates to medications at 3 months in the post-infectious group.
  • Steroids showed good response in the post-infectious group.

Conclusions:

  • A subset of daily headaches may stem from post-infectious pathology.
  • Early intervention for post-infectious headaches could prevent chronicity.
  • Further large-scale prospective studies are needed to validate these findings.