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Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
DNA Base Pairing02:27

DNA Base Pairing

Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
DNA Base Pairing02:27

DNA Base Pairing

Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
Structural Isomerism02:34

Structural Isomerism

Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can be...
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
Formation of Complex Ions03:45

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...

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Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
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Contiguous metal-mediated base pairs comprising two Ag(I) ions.

Dominik A Megger1, Célia Fonseca Guerra, Jan Hoffmann

  • 1Institute for Inorganic and Analytical Chemistry, University of Muenster, Corrensstr. 28/30, 48149 Münster, Germany.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|May 6, 2011
PubMed
Summary

Researchers created novel silver-ion mediated DNA base pairs, enabling enhanced metal incorporation for advanced DNA nanotechnology applications.

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Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
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Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry

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Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
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Thermochemical Studies of Ni(II) and Zn(II) Ternary Complexes Using Ion Mobility-Mass Spectrometry
16:11

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Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
09:37

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry

Published on: October 18, 2019

Area of Science:

  • Biochemistry
  • Chemical Biology
  • Materials Science

Background:

  • Metal-mediated base pairs offer site-specific functionalization of nucleic acids.
  • Previous methods allowed for single metal ion incorporation.

Purpose of the Study:

  • To report the formation of silver(I)-mediated Hoogsteen-type base pairs using modified nucleosides.
  • To investigate the stability and structural properties of these novel base pairs.
  • To explore their potential for increased metal ion functionalization in DNA.

Main Methods:

  • Synthesis of 1,3-dideaza-2'-deoxyadenosine and thymidine.
  • Formation of Ag(+)-mediated Hoogsteen-type base pairs.
  • Characterization using UV-Vis and circular dichroism (CD) spectroscopies, dynamic light scattering, and mass spectrometry.
  • Computational analysis using dispersion-corrected density functional theory (DFT).

Main Results:

  • Successfully formed stable Ag(+)-mediated Hoogsteen-type base pairs with two silver ions.
  • Demonstrated compatibility with various DNA sequence contexts and contiguous use.
  • Identified optimal stability in alternating purine-pyrimidine sequences.
  • DFT calculations revealed an Ag-Ag distance of 2.88 Å and significant Ag-Ag bonding contributing to stability.

Conclusions:

  • Novel Hoogsteen-type base pairs enable double silver ion incorporation, surpassing previous metal-mediated systems.
  • These findings enhance the functionalization capacity of nucleic acids with metal ions.
  • This advancement holds significant potential for DNA-based nanotechnology and materials science.