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[What is the evolution of metabolically normal obesity?]
Z Pataky1, E Bobbioni-Harsch, V Makoundou
1Service d'enseignement thérapeutique pour maladies chroniques, Centre collaborateur de l'Organisation mondiale de la santé, Département de médecine communautaire et de premier recours, HUG, Genève. Zoltan.Pataky@hcuge.ch
Revue Medicale Suisse
|May 7, 2011
Summary
Even "metabolically normal" obese individuals face risks. A study found 21% developed metabolic syndrome over three years, highlighting the need for regular medical monitoring for all obese patients.
Area of Science:
- Endocrinology
- Cardiology
- Metabolic Health
Background:
- The concept of
- metabolically normal obese subjects
- suggests a subgroup protected from obesity's cardiometabolic risks.
- However, a lack of standardized definitions hinders data interpretation and comparison.
Purpose of the Study:
- To investigate the long-term cardiometabolic health of metabolically normal obese subjects.
- To assess the incidence of metabolic syndrome in this subgroup over time.
Main Methods:
- Prospective analysis of over 1200 subjects.
- Baseline assessment of metabolic normality in obese individuals.
- Three-year follow-up to monitor cardiometabolic parameters and metabolic syndrome development.
Main Results:
- 21% of initially metabolically normal obese subjects developed metabolic syndrome within three years.
- Obese subjects who remained metabolically normal still exhibited significantly higher cardiometabolic parameters compared to normal-weight individuals at three years.
Conclusions:
- Metabolically normal obese subjects are not entirely protected from cardiometabolic complications.
- These individuals require closer medical monitoring and regular follow-up to prevent further weight gain and manage risks.
- The findings underscore the importance of weight management regardless of initial metabolic status.
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