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Published on: December 19, 2019
Plantago major protective effects on antioxidant status after administration of 7,12-Dimethylbenz(a)anthracene in
Gokhan Oto1, Suat Ekin, Hulya Ozdemir
1Department of Pharmacology, Faculty of Medical, Yuzuncu Yil University, Van, Turkey. okhanoto@hotmail.com
Aim:
The present study was designed to evaluate effects of Plantago major extract on oxidative status in Wistar albino rats administrated 7,12-dimethylbenz(a)anthracene (DMBA).
Methods:
Rats were divided into three equal groups of 6 animals each: Group 1 controls, group 2 treated with DMBA (100 mg/kg, single dose) and group 3 receiving the DMBA and the aqueous extract at 100 mg/kg/d for 60 days.
Results:
Significant decrease in catalase (P < 0.05), carbonic anhydrase (p ≤ 0.01), reduced glutathione (GSH) (P < 0.01) and total protein (P < 0.01) values was observed in the DMBA group compared with the healthy controls and DMBA + Plantago major groups.
Conclusion:
The results suggest preventive effects of Plantago major on DMBA induced oxidative damage in Wistar albino rats that might be due to decreased free radical generation.