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SNOLL. Sentinel node and occult (impalpable) lesion localization in breast cancer
1Radiology Department, St Helens and Knowsley Teaching Hospitals NHS Trust, Prescott, Liverpool, UK. thindr@aol.com
Clinical Radiology
|May 7, 2011
Summary
Dual radioisotopes for sentinel node and occult breast lesion localization (SNOLL) are effective and safe using a reduced dose. This combined technique reliably identifies impalpable lesions and sentinel nodes, supporting its recommendation as a standard procedure.
Area of Science:
- Nuclear medicine
- Surgical oncology
- Breast imaging
Background:
- Accurate localization of impalpable breast lesions and sentinel nodes is crucial for effective surgical treatment.
- Traditional methods may require higher radioisotope doses or additional imaging modalities.
Purpose of the Study:
- To evaluate the efficacy and safety of a dual radioisotope technique for sentinel node and occult breast lesion localization (SNOLL).
- To assess the feasibility of using a lower radioisotope dose compared to previous studies.
Main Methods:
- 127 SNOLL procedures were performed using dual radioisotopes.
- Impalpable lesions were localized using (99m)Tc MAA (1 MBq) for radio-guided occult lesion localization (ROLL).
- Sentinel nodes were localized using (99)Tc nanocolloid (20 MBq) injected periareolar region.
Main Results:
- 100% lesion localization was achieved with a 94.8% negative clearance margin.
- 100% sentinel node localization was achieved.
- Lower radioisotope doses for ROLL did not compromise localization accuracy for lesions or nodes.
Conclusions:
- Combined radioisotope use for SNOLL is feasible and reliable with reduced doses.
- The suggested lower radioisotope dose is effective compared to prior studies.
- This SNOLL method is recommended as a standard procedure.
