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Updated: Jun 2, 2026

Analysis of Physiologic E-Selectin-Mediated Leukocyte Rolling on Microvascular Endothelium
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Analysis of Physiologic E-Selectin-Mediated Leukocyte Rolling on Microvascular Endothelium

Published on: February 11, 2009

L-selectin--a dynamic regulator of leukocyte migration

Stefanie Wedepohl1, Figen Beceren-Braun, Sebastian Riese

  • 1Zentralinstitut für Laboratoriumsmedizin und Pathobiochemie, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany.

European Journal of Cell Biology
|May 7, 2011
PubMed

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Cytoskeletal Coordination in Cell Migration

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Intracellular Signaling Affects Focal Adhesions

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Activation of Integrins

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Mechanism of Lamellipodia Formation

Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
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